Publications 2012

Transcriptional activation of the adenoviral genome is mediated by capsid protein VI.

Schreiner S, Martinez r, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Marcinowski L, Ruzsics Z, Dobner T, Wodrich H.

PLoS Pathog. 2012 Feb;8(2):e1002549.

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.

Zuurbier L, Petricoin EF, Vuerhard MJ, Calvert V, Kooi C, Buijs-Gladdines J, Smits WK, Sonneveld E, Veerman AJ, Kamps WA, Horstmann M, Pieters R, Meijerink JP.

Haematologica. 2012 Apr 4.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

Brauer H, Strauss J, Wegner W, Müller-Tidow C, Horstmann M, Jücker M.

Cell Signal. 2012 Nov;24(11):2095-101. doi: 10.1016/j.cellsig.2012.07.017. Epub 2012 Jul 20.

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice.

Terziyska N, Alves CC, Groiss V, Schneider K, Farkasova K, Ogris M, Wagner E, Ehrhardt H, Brentjens RJ, Zur Stadt U, Horstmann M, Quintanilla-Martinez L, Jeremias I. PLoS One. 2012;7(12):e52798. Epub 2012 Dec 31.

Quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using amplicon-fusion-site polymerase chain reaction (AFS-PCR).

Weber A, Taube S, Zur Stadt U, Horstmann M, Krohn K, Bradtke J, Teigler-Schlegel A, Leiblein S, Christiansen H.

Exp Hematol Oncol. 2012 Nov 9;1(1):33.

Cerebral gray and white matter changes and clinical course in metachromatic leukodystrophy.

Groeschel S, I Dali C, Clas P, Böhringer J, Duno M, Krarup C, Kehrer C, Wilke M, Krägeloh-Mann I.,

Neurology. 2012 Oct 16;79(16):1662-70. doi: 10.1212/WNL.0b013e31826e9ad2. Epub 2012 Sep 19.

Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts

Gieseke F, Mang P, Viebahn S, Sonntag I, Kruchen A, Erbacher A, Pfeiffer M, Handgretinger R, Müller I.,

European Journal of Immunology 2012 May 15

Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5).

Pagel J, Beutel K, Lehmberg K, Koch F, Maul-Pavicic A, Rohlfs AK, Al-Jefri A, Beier R, Bomme Ousager L, Ehlert K, Gross-Wieltsch U, Jorch N, Kremens B, Pekrun A, Sparber-Sauer M, Mejstrikova E, Wawer A, Ehl S, Zur Stadt U, Janka G.

Blood 2012 Mar 26

Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation.

D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S. Eur J Immunol. 2012 Oct 8.

Hemophagocytic lymphohistiocytosis (HLH) in Syntaxin-11 deficient mice: T-cell exhaustion limits fatal disease

Kögl T, Müller J, Jessen B, Schmitt-Graeff A, Janka G, Ehl S, Zur Stadt U, Aichele P,

Blood 2012

Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.

Bode SF, Lehmberg K, Maul-Pavicic A, Vraetz T, Janka G, Stadt UZ, Ehl S.

Arthritis Res Ther. 2012 Jun 8;14(3):213

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes.

Bryceson YT, Pende D, Maul-Pavicic A, Gilmour KC, Ufheil H, Vraetz T, Chiang SC, Marcenaro S, Meazza R, Bondzio I, Walshe D, Janka G, Lehmberg K, Beutel K, zur Stadt U, Binder N, Arico M, Moretta L, Henter JI, Ehl S.

Blood 2012 Mar 22;119(12):2754-63. Epub 2012 Jan 31